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Dipl.-Ing. Ingmar Voigt

Alumnus of the Pattern Recognition Lab of the Friedrich-Alexander-Universität Erlangen-Nürnberg

Personalized healthcare with robust patient-specific models of anatomy and function
Project Description

Robust Physically-Constrained Modeling of the Mitral Valve and Subvalvular Apparatus

Mitral valve (MV) is often involved in cardiac diseases, with various pathological patterns that require a systemic view of the entire MV apparatus. Due to its complex shape and dynamics, patient-specific modeling of the MV constitutes a particular challenge. We propose a novel approach for personalized modeling of the dynamic MV and its subvalvular apparatus that ensures temporal consistency over the cardiac sequence and provides realistic deformations. The idea is to detect the anatomical MV components under constraints derived from the biomechanical properties of the leaflets. This is achieved by a robust two-step alternate algorithm that combines discriminative learning and leaflet biomechanics. Extensive evaluation on 200 transesophageal echochardiographic sequences showed an average Hausdorff error of 5.1mm at a speed of 9sec, which constitutes an improvement of up to 11.5% compared to purely data driven approaches. Clinical evaluation on 42 subjects showed, that the proposed fully-automatic approach could provide discriminant biomarkers to detect and quantify remodeling of annulus and leaflets in functional mitral regurgitation.



Voigt, Ingmar; Mansi, Tommaso; Ionasec, Razvan; Assoumou Mengue, Etienne; Houle, Helene; Georgescu, Bogdan; Hornegger, Joachim; Comaniciu, Dorin
Opens external link in new windowRobust Physically-Constrained Modeling of the Mitral Valve and Subvalvular Apparatus In: Fichtinger, Gabor; Martel, Anne; Peters, Terry (Eds.)
Proceedings of the 14th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI Toronto 18.-22.09.2011) Heidelberg : Springer 2011





Part of this work was implemented using the Simulation Open Framework Architecture.