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Dept. of Computer Sc. » Pattern Recognition » Our Team » Bock, Rüdiger » Statistical Deformation Model of the Optic Disk
Dipl.-Inf. Rüdiger BockAlumnus of the Pattern Recognition Lab of the Friedrich-Alexander-Universität Erlangen-NürnbergMy main research interest lies in the field of automatic detection of glaucoma in screening examinations to allow early diagnosis and therapy. Statistical Deformation Model of the Optic DiskStatistical deformation model of the optic disk Investigative Ophthalmology & Visual Science (IOVS), 2010, 51, ARVO E-Abstract 1774 (Poster as PDF, ARVO E-Poster)
Background and Purpose
Quantitative glaucoma indices commonly rely on geometric parameters of the optic nerve head (ONH) such as disk area or cup volume.
We provide dense descriptions of the ONH variability in glaucomatous cases presented by tissue deformations.
Data
Erlangen Glaucoma Registry
Dataset characteristics
Methods
Fundus image preprocessingNormalized optic nerve head images by eliminating disease independent variations such as
Non rigid image registrationCharacterization of inter subject ONH variability by dense deformation fields calculated between one reference image and image samples
Deformation based reference ONHONH reference image R that is characterized by the minimal average residual deformation over a sample set I is calculated by an iterative procedure:
Statistical deformation model (SDM) of ONHto provide a mathematically derived and biologically interpretable description of ONH variability in glaucomatous optic atrophy.
→ Identification of modes most discriminating between controls and glaucomatous
Results and Discussion
Deformation based reference ONHComparison of pixel wise averaging (left) and deformation based averaging Pixel wise averages are too smooth to indentify local structures. Deformation based averaging clearly shows the naturally shaped appearance of the cup (central bright spot).
Statistical Deformation Model of ONH in glaucomaFirst four PCA modes most discriminating between control and glaucoma
→ Biologically interpretable descriptions of ONH deformation in case of glaucoma
Conclusion
Statistical deformation modelling of ONH provides
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